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AvtorKadivec, Maksimiljan
Zakotnik, Branko
Šmid, Alojz, 1941-
Podkrajšek, Maja
Marolt-Mušič, Maja
Lešničar, Hotimir
Naslov Spremembe na skupni vratni arteriji po kombiniranem zdravljenju karcinomov glave in vratu = Changes in the common carotid artery following combined treatment of the head and neck carcinomas / Maksimiljan Kadivec ... [et al.]
Vrsta/vsebinatype of material prispevek na konferenci
Jezikslovenski
Leto2004
Fizični opisstr. 299-302
OpombeŽargi R, et al, editors. Zbornik predavanj 4. kongres otorinolaringologov Slovenije; 2004 maj 27-29; Otočec
12 ref.
BSDOCID106446
Predmetne oznakeHead And Neck Neoplasms - Surgery - Radiotherapy - Drug Therapy
Carotid Artery, Common - Pathology - Ultrasonography
Combined Modality Therapy
Mitomycin C
Bleomycin
Tunica Intima
Tunica Media
Neoplasm Staging
Glava in vrat, novotvorbe
Karotidna arterija skupna
Bleomicin
Kombinirani način zdravljenja
Novotvorba, stadij
Tunika intima
Tunika medija
PovzetekOBJECTIVE: Ultrasonography of the common carotid artery following surgery of head and neck carcinoma and combined adjuvant treatment with radio- and chemotherapy was performed with the aim of finding out whether arterial wall injuries are more acute in patients treated with combined adjuvant radio- and chemotherapy (mitomycin C and bleomycin) (Group B) than in those treated with adjuvant radiotherapy alone (Group A). PATIENTS AND METHODS: A total of 62 patients, 28 in Group A and 34 in Group B, were examined with ultrasound. The patients underwent ultrasonography of both common carotid arteries (ACC), which was performed bilaterally on three sites of longitudinal and transverse sections of ACC. The examinations included measurements of the thickness of tunica intima and media of ACC performed bilaterally. The measurement results for Groups A and B were compared. RESULTS: The mean age at diagnosis for patients from Groups A and B was 52 and 51 years, respectively. No statistically significant differences were observed between the two groups in terms of changes found in the arteries with respect to the patients' sex, their smoking habits, blood pressure, cardiovascular diseases and diabetes. There was also no difference between the two groups in tumour localizations and delivered doses. In Group A, the mean thickness of the tunica intima and media on the right of the neck was 0.83 mm (range 0.5-2.0 mm), and in Group B it was 0.86 mm (range 0.4-2.5 mm) (p=0.78). In Group A, the mean thickness of the tunica intima and media on the left of the neck was 1.20 mm (range 0.5-2.5mm), and in group B it was 0.92 mm (range 0.6-1.8 mm) (p = 0.28). No statistically significant difference was found between Groups A and B in the thickness of the tunica intima and media (on the right 0.83 mm vs. 0.86 mm, p =0.78; on the left 1.20 mm vs. 0.92mm, p=0.28). (Abstract truncated at 2000 characters).
NAMEN: Z ultrazvočnimi preiskavami na skupni vratni arteriji želimo ugotoviti, ali je pri bolnikih po operaciji karcinomov glave in vratu z dodatnim zdravljenjem s kombinacijo obsevanja in kemoterapije (Mitomycin C in Bleomycin) (skupina B) okvara žilne stene močneje izražena kot pri bolnikih, ki so zdravljeni samo z dodatnim obsevanjem (skupina A). MATERIAL IN METODE: Spomočjo ultrazvoka je bilo skupno pregledanih 62 bolnikov: 28 v skupini A in 34 v skupini B. Narejen je bil ultrazvočni pregled obeh skupnih vratnih arterij (ACC) v vzdolžnem in prečnem preseku, na treh mestih skupne vratne arterije obojestransko. Merili smo skupno debelino intime in medije (DIM) na skupnih karotidnih arterijah obojestransko. Primerjali smo rezultate meritev vskupini A in skupini B. REZULTATI: Povprečna starost ob odkritju diagnoze je v skupni A 51 let, v skupni B pa 52 let. Glede na spremembe na žilah ni opaznih nobenih statistično značilnih razlik med obema skupinama glede na spol, kajenje, krvni pritisk, bolezni srca in ožilja ali pri sladkorni bolezni. Glede na lokalizacijo tumorjev ni bilo statistično značilnih razlik med skupinama A in B, prav tako ne v prejeti dozi obsevanja. Povprečna debelina intime in medije na desni strani vratu pri skupini A je bila 0,83 mm (v razponu 0,5-2,0 mm) in pri skupini B 0,86 mm (v razponu 0,4-2,5) (p =0,78).Povprečna debelina intime in medije na levi strani vratu pri skupini A je bila 1,20 mm (v razponu 0,5-2,5 mm) in pri skupini B 0,92 mm (v razponu 0,6-1,8 mm) (p = 0,28). Opazili nismo nobene statistično pomembne razlike v debelini intime in medije med skupino A in skupino B (0,83 mm proti 0,86mm desno, p=0,78; 1,20mm proti 0,92 levo, p=0,28). (Izvleček skrajšan pri 2000 znakih).
COBISS.SI-ID17841625
Glej publikacijo TI=Medicinski razgledi, Supplement ISSN: 0353-3484.- Letn. 43, suppl. 3 (2004), str. 299-302