Preizkusite novo različico: COBISS+
 Vzajemna baza podatkov: COBIB.SI - Vzajemna bibliografsko-kataložna baza podatkov (Štev. zapisov: 5.072.697)

Izbrani zapis trajna povezava

AvtorFranić, Damir
Verdenik, Ivan
Meden-Vrtovec, Helena
Švab, Igor
Naslov Continuation of hormone replacement therapy in Slovenia : a prospective, randomized, controlled - 1-year follow-up / Damir Franić ... [et al.]
Vrsta/vsebinatype of material članek - sestavni del
Jezikangleški
Leto2006
Fizični opisstr. 110-118
Opombe32 ref.
BSDOCID122986
Predmetne oznakeEstrogen Replacement Therapy
Climacteric
Breast Neoplasms
Endometrial Neoplasms
Patient Education
Questionnaires
Survival Analysis
Prospective Studies
Randomized Controlled Trials
Bolnik, izobraževanje
Dojka, novotvorbe
Endometrijske novotvorbe
Estrogen, nadomestno zdravljenje
Klimakterij
Ankete
Naključno kontrolirane, klinične preiskave
Preživetje, analiza
Prospektivne študije
PovzetekObjectives: To evaluate the influence of educational intervention on the hormone replacement therapy (HRT) continuation rate in Slovenia after the publication of WHI results. Methods: We enrolled 125 early postmenopausal women in a 12-month prospective, randomized, controlled, multicentric study inSlovenia. The study group women (n = 62) attended educational lectures; the control group women (n = 63) did not. Data were collected from three types of questionnaire: before starting HRT, at follow-up visits at 3, 6, 9 and 12 month, after the educational lecture (study group). The continuation rate was measured on the basis of women's self-reports. The results were analyzed according to the "intention-to-treat" principle. The Cox proportional hazard model was used for the final analysis. Results: A gynecologist's suggestion, climacteric symptoms and quality of life were the prevailing reasons for starting HRT. The prevailing factors affecting continuation of HRT were: no orirregular previous OC use (hazard ratio 3.7), no educational lectures (hazard ratio 2.0) and climacteric disorders as the reason for start HRT (hazard ratio 2.1). In the women who discontinued HRT within the first 3 months, the fear of endometrial cancer, breast cancer and bleeding problems were statistically more significant than other factors (P=0.034). In the womenwho stopped HRT use within 6-12 months, the fear of breast and endometrial cancers increased substantially (P=0.002). Conclusions: Previous OC use and educational lectures on menopausal problems and HRT significantly improve the HRT continuation rate. The main reason for discontinuing HRT is fear of breast cancer, intensified by media.
COBISS.SI-ID21167065
Glej publikacijo TI=Maturitas ISSN: 0378-5122.- Letn. 54 (2006), str. 110-118